Human Embryonic &-Globin Gene Expression in Mouse-Human Hybrid Erythroid Cell Lines
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چکیده
The human a-globin-like embryonic I;-globin chains are present in abundance during the first 5 to 6 weeks of gestation. Subsequently, &-globin chains are present in fetal blood at a very low level, which is supplanted by the expression of a-globin chains. Adult individuals who are carriers of the (--SEA/) a-thalassemia deletion, in contrast to normal adults, have low levels of embryonic &-globin chains in their circulating erythrocytes. In this investigation, we constructed stable mouse-human hybrid cells with murine erythroleukemia cells bearing human chromosome 16, with either the normal a-globin gene cluster (am/) or the (--sEA/I
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تاریخ انتشار 2002